During the course of 2023 and 2024, the government of South Africa embarked on a consultative process to develop a National Strategy to Accelerate Action for Children (NSAAC). This strategy identifies 10 key priorities to accelerate action for children and teenagers, and presents 10 interventions which will make the most impact on children and teenagers. The strategy aims to target the many urgent needs of children in South Africa, so that the country might escape the inequality trap and build a thriving society where they have a bright future. Along with other critical needs, alcohol harms reduction is a core priority of the NSAAC. Priority number 7 of the strategy is to “Protect children & adolescents from all forms of abuse, violence, injuries and harmful substances”. Specific alcohol harms reduction strategies are among the 10 interventions likely to have the biggest impact on children. Intervention number 8 proposes to “Ban alcohol advertising (except at point of sale), introduce a minimum unit price for alcohol and restrict on-site liquor hours to midnight”. The DG Murray Trust (DGMT) spearheads numerous civil society actions to reduce heavy drinking in South Africa, and in partnership with the Presidency, has established an Accelerator to drive specific aims of the NSAAC. This literature review, commissioned by DGMT, feeds into this important endeavour. Its purpose is to detail the evidence for the harms caused by heavy drinking on children and adolescents, and to outline which policies, practices and advocacy interventions could reduce alcoholrelated harms to children and adolescents. This literature review also informs a policy brief which seeks to enhance the aims of the NSAAC.